Microsoft expands Azure AI and HPC infrastructure with AMD

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AI workloads are scaling faster than any single infrastructure approach can support — with more models, new agent-driven workloads and surging compute demand driving the need for greater specialization across the stack. To meet this need, Microsoft continues to evolve Azure’s infrastructure, including expanding its AI fleet with AMD’s most advanced AI and high-performance computing (HPC) solutions.

Our approach to AI infrastructure is designed to support the breadth of how AI systems are built and run. We closely work with industry innovators like AMD as well as our own purpose-built silicon and systems to provide customers with a comprehensive, open and heterogenous platform to achieve the best performance, cost and energy efficiency outcomes.

Building on our close collaboration with AMD, Microsoft is bringing AMD’s latest Helios AI platform and next-generation EPYC datacenter processors to Azure. These technologies will power three upcoming Azure offerings: HDv2 VMs for data processing, HXv2 VMs for electronic design automation (EDA) and ND MI455X v7 VMs for AI inference workloads.

Expanded infrastructure for inference, AI data systems and chip design

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Built for AI data systems — Azure HDv2

CPU infrastructure is essential to the performance and efficiency of modern AI systems. AI accelerators depend on high-density, power-efficient CPU compute to process data, coordinate workloads and keep pipelines running at scale. Without this, training jobs don’t have enough data to learn from, and agents don’t have enough capacity to perform tasks on behalf of customers. Azure HDv2 virtual machines are one of our latest offerings designed from the ground up to eliminate these bottlenecks and empower massive agentic workload adoption.

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September 15, 2026 19:08
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