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Medicines and Healthcare products Regulatory Agency gov.uk

Filters should be used during the administration of Parenteral Nutrition for patients in all care settings DSI/2026/011

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Alert

Safety Classified by Officially

Administration of parenteral nutrition without a filter has been associated with a number of adverse incidents including an embolism which resulted in a fatal outcome.

Administration of parenteral nutrition without a filter has been associated with a number of adverse incidents including an embolism which resulted in a fatal outcome. Healthcare professionals are advised to use integrated or add-on filters during the administration of parenteral nutrition for patients in all care settings. All parenteral nutrition solutions should be administered via a filter with a pore size no larger than 1.2μm. Where available, it is good practice to administer aqueous/lipid-free parenteral nutrition solutions with a 0.2μm filter.

  • parenteral nutrition is used to provide nutrients directly into the bloodstream bypassing the patient’s digestive system
  • administration of parenteral nutrition without a filter has been associated with adverse incidents, including an embolism which resulted in a fatal outcome
  • ensure all parenteral nutrition solutions are administered using a filter with a pore size no larger than 1.2µm
  • where the solution is aqueous/lipid free, it is good practice to use a filter with a pore size of 0.2µm during administration
  • filters and administration sets should be changed with each new parenteral nutrition container, based on the parenteral nutrition shelf-life, local infection control policies, and filter shelf-life
  • use of filters integrated into administration sets are preferred but add-on filters are a suitable alternative providing infection control guidelines are followed
  • report suspected adverse reactions associated with parenteral nutrition on a Yellow Card

    • Advice for Healthcare Professionals to Provide to Patients:

  • parenteral nutrition is used to provide nutrients directly into the bloodstream while avoiding the digestive system

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    Provenance

    Organization
    Medicines and Healthcare products Regulatory Agency — imported from official source
    Official source
    https://www.gov.uk/government/organisations/medicines-and-healthcare-products-regulatory-agency.atom ATOM
    Imported
    September 16, 2026 05:30
    Versions
    1 recorded
    Identity
    https://www.gov.uk/drug-device-alerts/filters-should-be-used-during-the-administration-...

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