Compound with the potential to treat drug-resistant HIV identified

Compound with the potential to treat drug-resistant HIV identified Published on the 28th August 2026 by ANSTO StaffShare to FacebookShare to BlueskyShare to LinkedIn Key Points A new compound has showed strong anti-viral activity against HIV, including some drug-resistant variants The HIV virus that causes AIDS remains a major global health challenge  The team used MX2 beamline to determine how the compound IC-2i bound to the HIV protein shell A large international team has developed a new compound that showed strong anti-viral activity against HIV, including some drug-resistant variants.  Despite major advances in HIV treatment, lifelong therapy is still required because the virus cannot be completely eradicated, creating a need for safer and more effective drugs that can overcome drug resistance. In research reported in the journal MedComm earlier this year, investigators combined and refined useful parts of previously studied HIV inhibitors to create smaller, more stable compounds that bind an additional, less mutation-prone region of the HIV capsid, or protein shell. The HIV-1 capsid (CA) has been validated as an antiviral target that plays critical roles in both t...